Abstract #1610

Multicenter Harmonization of Longitudinal DTI and NODDI of White Matter Microstructure after Acute TBI: A TRACK-TBI* Study

Lanya T. Cai^1,2, Amir Sadikov¹, Jaclyn Xiao¹, Jamie Wren-Jarvis¹, Ioanna Bourla¹, Esther L. Yuh^1,2, Christine L. Mac Donald³, Joseph T. Giacino⁴, Michael A. McCrea⁵, Nancy R. Temkin³, Claudia S. Robertson⁶, Amy J. Markowitz², Xiaoying Sun⁷, Sonia Jain⁷, Murray B. Stein⁷, Ramon Diaz-Arrastia⁸, David O. Okonkwo⁹, Geoffrey T. Manley², and Pratik Mukherjee^1,2

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Neurosurgery, University of California San Francisco, San Francisco, CA, United States, ³University of Washington, Seattle, WA, United States, ⁴Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States, ⁵Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Baylor College of Medicine, Houston, TX, United States, ⁷University of California San Diego, San Diego, CA, United States, ⁸University of Pennsylvania, Philadelphia, PA, United States, ⁹University of Pittsburgh Medical Center, Pittsburgh, PA, United States

Synopsis

Keywords: Traumatic Brain Injury, Neurodegeneration, TBI, White matter, DTI, NODDI

Motivation: Diffusion MRI-derived NODDI demonstrated promise as biomarkers of post-TBI long-term symptoms and clinical outcomes in single-center studies, but hasn't been validated in large-scale multi-center trials.

Goal(s): This study aimed to detect post-TBI white matter degeneration and its significance to outcomes using analysis methods incorporating RISH-based harmonization, followed by DTI and NODDI fitting.

Approach: Harmonized DTI and NODDI are analyzed for a longitudinal comparison between 2 weeks and 6 months post-TBI, and for associations with GOSE, RPQ, and WAIS-PSI outcomes.

Results: Widespread white matter degeneration was evident in longitudinal changes of DTI and NODDI. The 2-week metrics were predictive of 3 and 6-month outcomes.

Impact: This study applies RISH-based harmonization to a multi-shell, multi-center dMRI study that involved 7 scanners of different manufacturers and models with different software versions and pulse-sequence parameters. These efforts brought new insights into post-traumatic white matter injury and patient outcomes.

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