Abstract #1626

Validation of GRAPPATINI T2 mapping for detection of structural and biochemical changes in cartilage of ACLR patients

Rong Lu¹, Tian Xia², Xiao'ao Xue², Weijun Tang¹, Qing Li³, Caixia Fu⁴, Ying-Hua Chu³, Esther Raithel⁵, Tobias Kober^6,7,8, Tom Hibert^6,7,8, and Tingfang Hwang¹

¹Radiology, Huashan Hospital, Fudan University, Shanghai, China, ²Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China, ³MR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China, ⁴Application Developments, Siemens Shenzhen Magnetic Resonance Ltd., 518057 Shenzhen, China, Shanghai, China, ⁵Siemens Healthineers AG, Forchheim, Berlin, Germany, ⁶LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁸Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland

Synopsis

Keywords: Cartilage, MSK

Motivation: The study validated a non-invasive quantitative MR imaging for evaluating cartilage prognostic status after anterior cruciate ligament reconstruction (ACLR) as a technique against arthroscopic and histological measures.

Goal(s): To find the non-invasive biomarkers that can guide treatments and limit post-traumatic osteoarthritis (PTOA) in ACLR patients via quantitative cartilage morphometry analysis and biochemical assessments using GRAPPATINI T2 mapping.

Approach: This was a retrospective cohort study with level II evidence.

Results: Most knee cartilage subregions were thicker, larger in volume, and had higher T2 values in ACLR patients than in healthy controls. Partial cartilage parameters were significantly correlated with clinical scores.

Impact: Quantitative MRI parameters of cartilage could significantly advance non-invasive diagnosis, prognostication, and personalized management of cartilage degeneration.

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