Keywords: Myocardium, Cardiovascular, Contrast Mechanism, ihMT
Motivation: Imaging the cardiac conduction system (CCS) remains a significant challenge, since no imaging modalitiy has so far provided good contrast between the cardiac muscle and the embedded fibers that regulate normal heartbeat.
Goal(s): We aim to address this challenge by employing inhomogeneous Magnetization Transfer Imaging (ihMT).
Approach: We hypothesise that the conductive fibers exhibit unique dipolar order properties, due to the collagen sheath that surrounds them, and could thus be selectively isolated by ihMT.
Results: As a first step towards enhancing muscle-to-fiber contrast, this work investigated the biophysical parameters that govern the ihMT signal in the macromolecular environment of the CCS.
Impact: The assessment of the macromolecular environment of the cardiac conduction system (CCS) allows for a better understanding of its morphological architecture, and will enable us to design an ihMT sequence specifically sensitive to the challenging morphology of the CCS.
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