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Abstract #1638

Characterization of the cardiac conduction system with inhomogeneous Magnetization Transfer (ihMT): an ex-vivo study

Evgenios N. Kornaropoulos1, Arash Forodighasemabadi2, Lucas Soustelle1, Timothy Anderson1, Gopal Varma3, David C. Alsop3, Bruno Quesson4,5, Julie Magat4,5, Olivier Girard1, and Guillaume Duhamel1
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2IHU LIRYC, University of Bordeaux, Pessac, France, 3Radiology, Division of MRI Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 4IHU LIRYC, University of Bordeaux, Bordeaux, France, 5CRMSB, UMR 5536 CNRS, Université de Bordeaux, Bordeaux, France

Synopsis

Keywords: Myocardium, Cardiovascular, Contrast Mechanism, ihMT

Motivation: Imaging the cardiac conduction system (CCS) remains a significant challenge, since no imaging modalitiy has so far provided good contrast between the cardiac muscle and the embedded fibers that regulate normal heartbeat.

Goal(s): We aim to address this challenge by employing inhomogeneous Magnetization Transfer Imaging (ihMT).

Approach: We hypothesise that the conductive fibers exhibit unique dipolar order properties, due to the collagen sheath that surrounds them, and could thus be selectively isolated by ihMT.

Results: As a first step towards enhancing muscle-to-fiber contrast, this work investigated the biophysical parameters that govern the ihMT signal in the macromolecular environment of the CCS.

Impact: The assessment of the macromolecular environment of the cardiac conduction system (CCS) allows for a better understanding of its morphological architecture, and will enable us to design an ihMT sequence specifically sensitive to the challenging morphology of the CCS.

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