Abstract #1720

Longitudinal assessment of brain functional connectivity in depressed patients according to resting-state fMRI

Zi-You Qiu¹, Chin-Hung Chen ^2,3, Yuan-Hsiung Tsai ^2,4, and Jun-Cheng Weng ^1,3

¹Department of Medical Imaging and Radiological Sciences, and Department of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, fMRI (resting state)

Motivation: Given that suicidal ideation (SI) is closely related to social development, it is important to understand the associations between network function and SI (or the non-suicidal ideation, NS) in patients with depression.

Goal(s): We aim to investigate brain function changes in depressed patients with SI and NS between baseline (Time 1, TP1) and follow-up (Time 2, TP2; after one year of therapy).

Approach: Paired t-tests, repeated-measure ANCOVA, and network-based statistical analysis were used.

Results: We found differences in functional activity after treatment, the results surrounded the DMN region in each group. NBS revealed significantly increased functional interconnections of subnetworks after treatment.

Impact: Our findings provide more information about potential neural biomarkers of various depressive disorders.

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