Keywords: Psychiatric Disorders, Psychiatric Disorders, Schizophrenia, Glymphatic, Perivascular Space, water clearance
Motivation: Perivascular spaces(PVS) are fluid-filled spaces that surround blood vessels in the brain. While dilated PVS(dPVS) play an important role, investigations into dPVS in schizophrenia are poorly understood.
Goal(s): In this study, we aim to explore the potential of dPVS quantification as a biomarker for schizophrenia.
Approach: For volumetric assessment, we segmented the dPVS in the white matter(WM) and basal ganglia(BG), and calculated the volumes and numbers of dPVS for each subject.
Results: Our findings reveal differences in dPVS numbers and volumes among schizophrenia subgroups, especially in treatment-resistant schizophrenia(TRS) which showed smaller dPVS volumes compared to other groups in both WM and BG.
Impact: Our study offers insights into the potential of dPVS quantification as a biomarker for schizophrenia. We observed differences in total dPVS volumes and number of dPVS components between different schizophrenia subgroups and found significant results especially in TRS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords