Keywords: Psychiatric Disorders, Brain, Obesity, Anorexia Nervosa, quantitative T1
Motivation: The key structure for maintaining energy balance is the hypothalamus (HT), a small structure organized in multiple nuclei difficult to individualize with MR imaging.
Goal(s): To study in vivo the modulation in Obesity and Anorexia Nervosa of morphometry and microstructure of HT nuclei involved in food networks.
Approach: Characterization of T1 and volumes of HT nuclei (Neudorfer atlas) of 28 young women (13 Controls, 7 AN, 8O) using 3D-MP2RAGE 7T MRI.
Results: Differences in T1 values and volumes were observed in Obese and AN in HT nuclei involved in food networks (bilateral AN, left PVN)
Impact: Quantitative high resolution T1 MRI at 7T allows to characterize the morpho-structural modulation of HT nuclei involved in food networks in obesity and AN. These biomarkers may have a crucial role to monitor adaptation of food networks during therapeutic interventions.
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