Keywords: Psychiatric Disorders, Brain Connectivity, Methamphetamine addiction, Resting-state functional connectivity, Effect connectivity, Dorsal raphe nucleus, Ventral tegmental area, Graph theory
Motivation: This study aims to investigate the role of the dorsal raphe nucleus (DRN) and the ventral tegmental area (VTA) in the mechanism of methamphetamine (MA) induced nerve injury.
Goal(s): To further explore the neural mechanism of MA addiction.
Approach: Analyze the functional connections, effect connections, and graph theory analysis between DRN and VTA with other brain regions.
Results: MA-dependent patients showed enhanced FC between the DRN and multiple brain regions in the whole brain. Topological analysis showed that multiple topological attributes of the dorsal raphe nucleus were abnormal.
Impact: Aberrations in the connecome of the dorsal raphe nucleus among individuals with methamphetamine dependence may provide novel insights into the neural mechanisms underpinning addiction to this substance
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