Keywords: Psychiatric Disorders, Neuro, Morphometric similarity
Motivation: Chronic Insomnia Disorder (CID) influences various levels of brain organization, spanning macroscopic structures to microscopic genomics, the connection between genomic variations and structural brain alterations in CID was not clear.
Goal(s): This study analyzed structural brain alterations-related genomes in CID.
Approach: Using and morphometric similarity (MS) and imaging-transcription alanalysis
Results: The study identified MS reductions in the parietal and limbic regions, as well as enhancements in the temporal and frontal regions in CID patients. The study also discovered spatial correlations between MS alterations and genes associated with excitatory and inhibitory neurons, as well as genes implicated in chronic neuroinflammation processes.
Impact: This study bridges the gap between cortical structural changes and the molecular mechanisms in Chronic Insomnia Disorder (CID), shedding light on the genetic basis and brain alterations associated with CID.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords