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Abstract #1749

Accelerated Diffusion Tensor Imaging using A Diffusion Generative Deep Learning Model

Phillip Andrew Martin1,2, Brian Toner2,3, Maria Altbach2,4, and Ali Bilgin1,2,3,4
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Medical Imaging, University of Arizona, Tucson, AZ, United States, 3Applied Mathematics, University of Arizona, Tucson, AZ, United States, 4Biomedical Engineering, University of Arizona, Tucson, AZ, United States

Synopsis

Keywords: AI Diffusion Models, Diffusion Tensor Imaging

Motivation: High-quality diffusion tensor imaging involves fitting a large number of diffusion-encoded images to a tensor model. This challenging process requires long scans and is vulnerable to motion artifacts. There’s a need for accelerated acquisitions while preserving robust diffusion tensor estimates.

Goal(s): To develop a generative diffusion model that produces high-quality tensor metrics using a few diffusion-encoded images.

Approach: The proposed generative model was trained using 300 randomly selected subjects from the Human Connectome Project Dataset and tested on 20 subjects.

Results: Our model demonstrates the ability to generate high-quality tensor metrics for as few as 3 DWIs.

Impact: This study demonstrates that a generative diffusion model can produce high-quality tensor metrics with significant reduction in scan time, potentially eliminating image distortions and artifacts.

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Keywords