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Abstract #1755

Beyond Differences: Cross-Subject and Cross-Dataset fMRI Brain Decoding of visual stimuli

Matteo Ferrante1, Tommaso Boccato2, Furkan Ozcelik3, Rufin VanRullen4, Rufin VanRullen4, and Nicola Toschi2
1Biomedicine and prevention, University of Rome Tor Vergata, Rome, Italy, 2University of Rome Tor Vergata, Rome, Italy, 3CerCo, University of Toulouse III Paul Sabatier, Toulouse, France, 4CNRS, CerCo, ANITI, TMBI, Univ. Toulouse, Toulouse, France

Synopsis

Keywords: AI Diffusion Models, fMRI (task based), brain decoding, fMRI

Motivation: Brain decoding has been limited by the need for large data amounts and subject-specific methodologies. Current techniques require extensive scanning, which is costly and time-consuming, restricting their applicability.

Goal(s): The study aims to establish a novel, more efficient approach for cross-subject brain decoding of visual stimuli.

Approach: Using the NSD we applied regularized ridge regression to align brain activity across different subjects on common stimuli representations, employing the state-of-the art Brain-Diffuser pipeline for decoding and image reconstruction.

Results: The ridge regression alignment method surpassed others, enabling consistent cross-subject decoding with significantly reduced data—demonstrating feasibility and a potential 90% scan time reduction.

Impact: A reliable technique for cross-subject, -scanner and -field strength alignment can pave the way for efficient brain decoding without the need for extensive data collection and/or ultra-high field strengths.

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Keywords