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Abstract #1778

Higher oxygen extraction fraction in coronary artery disease is associated with lower cognition and cardiorespiratory fitness in males.

Ali Rezaei1,2, Safa Sanami1,2, Brittany Intzandt3, Stefanie Tremblay1,2, Dalia Sabra1,2,4, Zacharie Potvin-Jutras1,2, Julia Huck5,6, Christine Gagnon2, Amelie Mainville-Berthiaume7, Lindsay N Wright1,2, Dajana Vuckovic8, Josep Iglesies-Grau2,9, Thomas Vincent2, Mathieu Gayda2, Anil Nigam2, Louis Bherer2,9,10, and Claudine J Gauthier11,12
1Quantitative Physiology Imaging Lab (QPI Lab), Department of Physics, Concordia University, Montreal, QC, Canada, 2Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, 3Hurvitz Brain Sciences Program, Clinical evaluative Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 4Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada, 5Department of Radiology, Université de Sherbrooke, Sherbrooke, QC, Canada, 6Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Faculty of Science, University of Sherbrooke, Sherbrooke, QC, Canada, 7Department of Psychology, Concordia University, Montreal, QC, Canada, 8Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada, 9Department of Medicine, Université de Montreal, Montreal, QC, Canada, 10Research Center, Institut Universitaire de Gériatrie deMontréal, Montreal, QC, Canada, 11Physics, Concordia University, Montreal, QC, Canada, 12PERFORM Centre, Concordia University, Montreal, QC, Canada

Synopsis

Keywords: Heart Failure, Oxygenation, Quantitative Susceptibility Mapping (QSM), Venography, Cardiorespiratory fitness, Cognition

Motivation: There is a lack of knowledge about the physiological underpinnings of the effects of coronary artery disease (CAD) on human brain health.

Goal(s): Here we investigated the effect of CAD on brain oxygen extraction fraction (OEF)

Approach: Using quantitative susceptibility mapping (QSM) and its relation to cognitive performance and cardiorespiratory fitness.

Results: The results of the sex-disaggregated analysis in a preliminary dataset show that CAD male patients have significantly higher OEF in whole gray matter, frontal, occipital, and temporal lobes. Furthermore, higher OEF in males is associated with lower cognitive performance, and higher OEF is associated with lower VO2max.

Impact: Sex differences in the effects of coronary artery disease (CAD) on brain health are unknown. Our results show that CAD increases OEF, and that higher OEF is associated with lower cognitive performance , and lower cardiorespiratory fitness in males.

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Abstract

Keywords