Keywords: Heart Failure, Diabetes, global longitudinal strain; heart failure with preserved ejection fraction; diabetes mellitus; prognosis
Motivation: While diabetes mellitus has a high prevalence in HFpEF and being associated with poorer outcomes, limited data are available on the cardiac MRI features of diabetic HFpEF
Goal(s): We aimed to explore imaging features including tissue characterization and myocardial deformation in diabetic HFpEF patients by MRI, and investigate its prognostic value for adverse outcomes
Approach: Feature-tracking derived strain and strain rates parameters and myocardial fibrosis were assessed by cardiac MRI in patients with diabetic HFpEF
Results: Diabetic HFpEF patients were characterized by more impaired strains and myocardial fibrosis. Tissue characterization and global longitudinal strain obtained from MRI-FT provided incremental value for risk prediction
Impact: Our findings suggested that MRI-derived variables especially GLS played a crucial role in risk stratification and predicting worse prognosis in diabetic HFpEF, which could assist in identifying high-risk patients and guide therapeutic decision making.
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