Keywords: Heart Failure, Perfusion, Heart failure, preclinical imaging, HFpEF animal model, MRI
Motivation: Addressing the challenges in heart failure with preserved ejection fraction (HFpEF) diagnosis, the study aimed to validate cine-ASL as a precise non-invasive imaging tool.
Goal(s): The study sought to explore nuanced aspects of HFpEF, enabling a better understanding of its complexities through advanced imaging techniques.
Approach: Employing advanced cardiac magnetic resonance imaging with arterial spin labeling (cine-ASL), our study investigates longitudinally myocardial perfusion in a two-hit mouse HFpEF model.
Results: Significant reductions in myocardial perfusion in a HFpEF-like mouse model revealed the technique's efficacy in capturing HFpEF-related changes.
Impact: These findings highlight early coronary microcirculation impairment in HFpEF-like myocardium, shedding light on potential diagnostic biomarkers for HFpEF and paving the way for improved early diagnosis and understanding of the HFpEF pathophysiology.
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