Meeting Banner
Abstract #1830

Evidence of impaired dACC glutamate modulation under task-specific motor control in obsessive compulsive disorder (OCD) using 1H fMRS

Jeffrey A Stanley1,2, Jillian M Eichstaedt2,3, Dalal Khatib1,2, Phil Easter1, Rebecca Neill1, Usha Rajan1, Julia Bellamy1, David R Rosenberg1, and Vaibhav A Diwadkar1,2
1Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States, 2Brain Imaging Research Division, Wayne State University, Detroit, MI, United States, 3Translational Neuroscience Program, Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Spectroscopy, Spectroscopy, 1H MRS, fMRS, OCD

Motivation: The neurobiological mechanisms of poor top-down motor control in OCD are not well understood.

Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses in OCD compared to healthy controls.

Approach: 1H fMRS was conducted in adolescents with OCD and healthy controls.

Results: Task-specific impairments to the dACC glutamate modulation were observed in OCD compared to healthy controls.

Impact: These results providing compelling evidence towards characterizing neurosignaling changes in OCD pathophysiology.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords