Keywords: Spectroscopy, Molecular Imaging, GABA, Spectral editing, MRSI
Motivation: Robust B0 and B1+ detection of GABA+ and Glx in 3D or whole brain MRSI using spectral editing is challenging at 7T.
Goal(s): To simultaneously detect GABA+ and Glx in multi-regions and generate 3D maps using SLOW-editing for human brain at 7T.
Approach: SLOW-EPSI was performed on 5 healthy volunteers.
Results: Our method is robust to [-0.3 ppm, +0.3 ppm] B0 and [40%, 250%] B1+ for GABA+/Glx editing. 9-minute acquisition is sufficient for any arbitrarily shaped volume quantification. 18-27 minutes acquisition is sufficient for 3D mapping of GABA+. 9-18 minutes acquisition is sufficient for 3D mapping of Glx.
Impact: Our work presents a large 3D or whole-brain MRSI tool for GABA+ and Glx quantification and mapping at 7T, which allows clinicians to examine changes in GABA+ and Glx in the brain for any arbitrarily shaped volume.
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