Abstract #1832

Weight loss predicts the modulation of dACC glutamate during inhibitory control that is specific to food-cues: Evidence from ¹H fMRS

Jillian M Eichstaedt^1,2, Rachel Sochocki³, Dalal Khatib², Nicole Miller⁴, Vaibhav A Diwadkar², Paul Burghardt^1,3, Amy Rothberg⁴, and Jeffrey A Stanley^1,2

¹Translational Neuroscience Program, Wayne State University, Detroit, MI, United States, ²Brain Imaging Research Division, Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, United States, ³Department of Nutrition and Food Science, Wayne State University, Detroit, MI, United States, ⁴Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Spectroscopy, Spectroscopy, fMRS, 1H MRS

Motivation: The neurobiological mechanisms involved in poor weight loss maintenance are not understood.

Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses after completion of a clinical weight loss program.

Approach: ¹H fMRS was conducted in a pilot sample who had completed a clinical weight loss program.

Results: The presence of food cues as the stimuli influenced the glutamate modulation during inhibitory control responses.

Impact: With further investigation, our preliminary evidence of a food-cue specific difference in glutamate modulation may fuel better treatment plans to support more successful maintenance of weight loss.

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