Keywords: Spectroscopy, Spectroscopy, Succinate
Motivation: To measure succinate in brain during circulatory arrest in a piglet model of cardiac bypass.
Goal(s): Dynamic measurement of succinate using 3T MR spectroscopy
Approach: Spectral fits of the archived data were used to create dynamic plots of succinate, to provide statistics, and to generate simulated spectra for validation.
Results: Elevation of succinate during circulatory arrest was observed and validated. Fitting bias was evaluated over the linewidths and signal-to-noise S/Ns of the archived data. Succinate increase did not appear to be dependent on bypass temperature. Succinate elevation was not observed with antegrade cerebral perfusion.
Impact: Elevated succinate during ischemia has been identified as a source of ischemic-reperfusion injury. The ability to measure increased succinate during ischemia plus the ability to intercede with succinate inhibitors may have important consequence prior to re-perfusion in bypass and stroke.
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