Keywords: Spectroscopy, Spectroscopy, 7T ultra high field MRS, Cognition
Motivation: This study aims to contribute novel insights into the potential cognitive role of myo-inositol and its implications for brain metabolism using 7 Tesla magnetic resonance spectroscopy (7T-MRS).
Goal(s): Our primary goal was to determine if myo-inositol concentrations within the posterior cingulate cortex (PCC) influence cognitive performance.
Approach: Ultra-high field 7T-MRS was used to measure myo-inositol concentrations in relation to cognitive performance, as assessed with the Trail-Making-Test (TMT-A/B). Data analysis involved multiple linear regressions with covariate control and bootstrapping for robustness.
Results: Our study reveals a significant (p<0.05) positive association between higher myo-inositol levels in the PCC and enhanced cognitive performance in TMT-A/B.
Impact: This study suggests the potential of myo-inositol as a biomarker for cognitive functioning. Furthermore, the findings contribute to our understanding of brain neurochemistry, supporting the advancement of personalised medicine for cognitive impairments.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords