Keywords: Spectroscopy, Spectroscopy, LCModel
Motivation: The actual B0 resonance field of 3T scanners is different between the three major MR vendors.
Goal(s): Here, we report the effect on metabolite quantification of using basis sets at different B0 fields than the B0 frequency of the measured in vivo MRS data.
Approach: Basis sets were simulated at thirteen different B0 fields. Semi-LASER MRS data measured from the posterior cingulate cortex at 3T were fitted using LCModel.
Results: Results show that biases in metabolite concentrations were within 1% when the basis set B0 frequencies were within ±0.5 MHz from the actual scanner frequency.
Impact: A single sequence-specific basis set can be used to analyze harmonized spectroscopic data collected on clinical 3T scanners from different vendors that operate at different frequencies.
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