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Abstract #1886

Quantitative in vivo imaging of median and ulnar nerves using ultrashort echo time (UTE) MRI: a feasibility study

James Lo1,2, Melissa Lou Silva1, Dina Moazamian1, Jiyo S Athertya1, Yuanshan Wu2,3, Hyungseok Jang1, Yajun Ma1, Eric Y Chang1,3, Saeed Jerban1, and Sameer Shah1,2,3,4
1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2Department of Bioengineering, University of California San Diego, San Diego, CA, United States, 3Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, 4Department of Orthopedic Surgery, University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Peripheral Nerves, Nerves, Median, Ulnar

Motivation: Improvements in the medical imaging of nerves have broad medical applications in the diagnosis, tracking, and management of peripheral nerve disease, injury, and treatment.

Goal(s): We aim to demonstrate the feasibility of quantitative in vivo imaging of median and ulnar nerves using ultrashort echo time (UTE) MRI.

Approach: UTE magnetization transfer (MT) prepared Cones (UTE MT-Cones), UTE MT Fat-Sat-Cones, and UTE Multi-echo-T2-FS-Cones sequences were performed in nine healthy adults using a clinical 3T scanner.

Results: Cross-sectional area (CSA), T2*, MMF, and all MTR values were lower in the ulnar nerve, but the differences were significant only for CSA, non-fat-sat MTR 800-2k and 500-10k.

Impact: This demonstration of high-contrast, quantitative imaging of the wrist nerve has considerable potential in practical applications for managing and monitoring nerve disease, injury, and treatment.

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Keywords