Abstract #1894

Feasibility of diffusion-weighted and magnetization transfer imaging of the tibial nerve in vivo using 7 Tesla: a pilot reproducibility study

Ratthaporn Boonsuth¹, Rebecca S. Samson¹, Amy R. McDowell², Philippa Bridgen^3,4,5, Peter J Lally^4,6,7, John S. Thornton^8,9, Claudia A. M. Gandini Wheeler-Kingshott^1,10,11, and Marios C. Yiannakas¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Queen Square Centre for Neuromuscular Diseases, University College London, London, United Kingdom, ³Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁴London Collaborative Ultra high field System (LoCUS), London, UK, Kings College London, London, United Kingdom, ⁵Guys and St Thomas’ NHS Foundation Trust, Kings College London, London, United Kingdom, ⁶Department of Bioengineering, Imperial College London, London, United Kingdom, ⁷Centre for Care Research and Technology, UK Dementia Research Institute, London, United Kingdom, ⁸Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁹Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ¹⁰Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ¹¹Digital Neuroscience Centre, IRCCS Mondino Foundation, Pavia, Italy

Synopsis

Keywords: Peripheral Nerves, Diffusion Tensor Imaging, Magnetization Transfer

Motivation: Quantitative and semi-quantitative magnetic resonance imaging investigations of the peripheral nerves in vivo using 7 Tesla are currently limited.

Goal(s): To obtain standard diffusion tensor imaging (DTI) metrics and magnetization transfer ratio (MTR) in the healthy tibial nerve in vivo and to assess the reproducibility of these measures.

Approach: Reproducibility was assessed through repeated measurements (scan-rescan) and calculation of the coefficient of variation between measurements.

Results: The reproducibility assessment results are presented along with normative DTI and MTR measures in the tibial nerve, which can serve as reference in future studies of pathological conditions affecting the lower peripheral nerves.

Impact: This pilot study demonstrates the feasibility of using 7 Tesla magnetic resonance imaging to assess the healthy tibial nerve in vivo using diffusion-weighted and magnetization transfer imaging, opening up the possibilities to investigate lower peripheral neuropathies with higher spatial resolution.

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