Keywords: Neurotransmission, Spectroscopy
Motivation: Examining the impact of the excitatory-inhibitory balance on cognitive function in healthy individuals holds great significance in research.
Goal(s): Exploring the excitatory-inhibitory balance at the neurotransmitter level and studying the relationship between excitatory-inhibitory balance and cognitive functions.
Approach: The study involved the collection of glutamate and γ-aminobutyric acid using magnetic resonance spectroscopy in 268 healthy participants, alongside the assessment of cognitive function in the subjects.
Results: In the anterior cingulate cortex, we observed a positive correlation between glutamate and γ-aminobutyric acid levels. Additionally, we found that a higher ratio of excitatory balance was associated with improved working memory performance at this specific location.
Impact: This study enhances our understanding of the excitatory-inhibitory balance at the neurotransmitter level and identifies a correlation between the level of excitatory inhibition and cognitive function. These findings provide valuable insights into the impact of excitatory inhibition on cognitive function.
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