Abstract #1929

Motor hand area GABA could be a physiological switch between motor network and default mode network connectivity

Evan Cyril Edmond^1,2, William T Clarke¹, Ioana-Florentina Grigoras^1,2, Justin W Andrushko^1,3, Jacob M Levenstein^1,4, Caroline Nettekoven^1,2, Emily L Hinson¹, Jon Campbell¹, Adam Steel^1,5, Uzay Emir^1,6, Martin R Turner¹, and Charlotte J Stagg^1,2

¹Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ²Brain Network Dynamics Unit, Oxford, United Kingdom, ³Department of Sport, Exercise and Rehabilitation, University of Northumbria, Newcastle, United Kingdom, ⁴USC Thompson Institute, University of the Sunshine Coast, Birtinya, Brisbane, Queensland, Australia, ⁵Department of Psychology and Brain Sciences, Dartmouth College, Hanover, NH, United States, ⁶School of Health Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Neurotransmission, Neuroscience

Motivation: The functional role of Inhibitory tone in the motor cortex is not completely understood. Previous work has been limited by the coarse spatial resolution in single-voxel spectroscopy.

Goal(s): We applied a novel high spatial resolution MR spectroscopic imaging technique to test the relationship between inhibitory tone and motor network (MN) connectivity.

Approach: We performed voxel-wise analysis of neurochemical data to correlate measures of inhibitory and excitatory tone with age as a confounder, MN and default mode network (DMN).

Results: In the motor hand areas, we demonstrated a reciprocal correlation of inhibitory tone with MN and DMN connectivity. Inhibitory tone could “switch” node connectivity.

Impact: The connectivity of key motor network nodes could be influenced by their inhibitory tone and the excitation–inhibition difference. This finding advances the understanding of motor network function and could be a target for modulation in clinical settings.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.