Abstract #1997

Evaluation of multi-delay arterial spin labeling MRI-based measures of cerebral blood flow in a PET/MRI study of aging

Meher R. Juttukonda^1,2, Jessie Fanglu Fu^1,2, Arun H. Garimella¹, Nathaniel D. Mercaldo^1,2, Hsiao-Ying Wey^1,2, Andrew Salvatore¹, Brad C. Dickerson^3,4, and Julie C. Price^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Neurology, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Neurology, Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Arterial Spin Labelling, Perfusion, PET/MR

Motivation: Arterial spin labeling (ASL) MRI with a single post-labeling delay may not be appropriate for quantifying cerebral blood flow (CBF) in older participants or individuals with Alzheimer’s disease (AD).

Goal(s): To evaluate reliability of multi-delay versus single-delay ASL and their associations with [¹⁵O]water positron emission tomography (PET) using simultaneous PET/MRI in older adults.

Approach: We investigated 4-week test-retest reliability using intra-class correlation (ICC) and assessed Spearman’s correlations between ASL and PET in young and older controls (n=12) and AD patients (n=3).

Results: ICC values were similar between ASL approaches but exhibited regional differences. Multi-delay ASL-based CBF was correlated with PET in more regions-of-interest.

Impact: Multi-delay arterial spin labeling MRI provides CBF measures with good intermediate-term reliability that are strongly correlated with gold-standard [15O]water PET when studying older adults and AD patients.

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