Keywords: Arterial Spin Labelling, Arterial spin labelling, Asymmetric magnetization transfer
Motivation: This study explores the asymmetric magnetization transfer (MT) effects on recently developed blood-brain barrier integrity (BBB-ASL) technique, with a focus on different neck labeling gradient polarities.
Goal(s): Validation of the asymmetric MT effect in BBB-ASL.
Approach: BBB-ASL parameters of arrival transit time (ATT), intra-voxel transit time (ITT), exchange time (Tex) and CBF were estimated by our custom MATLAB program based on a two-compartment model.
Results: Asymmetric MT effect changes not only depending on physical factors but also on the severity of the tissue. The difference might be related to changes in ITT and ATT.
Impact: This study explores the asymmetric magnetization transfer (MT) effects on BBB-ASL with MCAO model rats. Asymmetric MT effect changes not only depending on physical factors such as magnetic field inhomogeneity but also on the severity of the tissue.
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