Keywords: Arterial Spin Labelling, Perfusion, Arterial Spin Labelling, Normal Development
Motivation: There is lacking understanding of hemodynamic changes in children and their impact on MRI perfusion quantification.
Goal(s): We aim to investigate age-related hemodynamic changes in developing brain.
Approach: Perfusion parameters from single- and multi-delay Arterial Spin Labeling (ASL) MRI of MR-negative children are analyzed.
Results: We found significant age-dependent differences between perfusion quantification with single- and multi-delay approaches. ATT followed a non-linear distribution in age and was heterogeneous across vascular territories Our findings support the use of multi-delay ASL for improved perfusion assessment in children and provide better understanding of hemodynamic changes in developing brain.
Impact: This is the first study to investigate age-related arterial transit-time changes in children and their impact on perfusion quantification with perfusion MRI. Our findings prompt improved understanding of age-related perfusion changes and standardization of hemodynamic parameters in the pediatric cohort.
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