Abstract #2010

Measuring intra-to-extra-vascular cerebral water-transport in patients with small vessel disease using 3D T2-prepared time-encoded pCASL

Elles Elschot¹, Damon Verstappen¹, Paulien Voorter¹, Maud van Dinther², Julie Staals², Robert van Oostenbrugge², Matthias van Osch³, Jacobus Jansen¹, Walter Backes¹, and Lena Vaclavu⁴

¹Department of Radiology and Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ²Department of Neurology, Maastricht University Medical Center +, Maastricht, Netherlands, ³Department of Radiology, C.J. Gorter MRI Center, Leiden, Netherlands, ⁴C.J. Gorter MRI Center, Leiden, Netherlands

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, cerebral small vessel disease

Motivation: The blood brain barrier (BBB) is damaged in patients with cerebral small vessel disease (cSVD).

Goal(s): To study the role of subtle BBB impairment in cSVD by measuring water-transport over the vessel wall.

Approach: T₂-prepared time-encoded pCASL was applied in cerebral small vessel disease (cSVD) patients and healthy controls.

Results: T₂ variations between the groups showed no significance in this preliminary sample yet. However, T₂-values tend to decay earlier in VCI patients compared to HC. This suggests earlier water-transport from blood to tissue, possibly referring to stronger BBB impairment. Moreover, broader distributions of T₂-values seem to indicate larger heterogeneity in the VCI-group.

Impact: This study applied T₂-prepared time-encoded pCASL in cerebral small vessel disease (cSVD) patients and healthy controls to study subtle BBB-damage. Although T₂-values showed no significant differences yet, the T₂-values seem to decay earlier in cSVD, suggesting earlier water-transport into tissue.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.