Abstract #2015

Improving pCASL CBF mapping in neonates and adults with enhanced background suppression and complex subtraction

Zhiyi Hu¹, Dengrong Jiang², Jennifer Shepard³, Yuto Uchida², Kenichi Oishi², Peiying Liu^2,4, Doris Lin², Vivek Yedavalli², Aylin Tekes², W. Christopher Golden³, and Hanzhang Lu^1,2,5

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Arterial Spin Labelling, Perfusion

Motivation: Standard arterial spin labeling (ASL) uses modest background-suppression to enhance SNR, which may not be optimal in reducing noise.

Goal(s): Our goal was to further improve the SNR in ASL and reliably measure the cerebral blood flow (CBF) in low-perfusion scenarios such as neonates.

Approach: We utilized an enhanced background suppression to minimize the signal from static background tissue. Complex subtraction of control/labeled signals was done to correct the magnetization sign-switching in between.

Results: Enhanced background suppression combined with complex subtraction improved the reliability of CBF measurement in both neonates and adults, particularly benefiting the quality of neonatal CBF mapping.

Impact: The improvement of SNR in ASL through enhanced background suppression coupling complex subtraction can facilitate the quality of cerebral blood flow measurement. The benefits are more pronounced in low-perfusion scenarios, such as bolstering the reliability of neonatal ASL.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.