Keywords: Arterial Spin Labelling, Blood
Motivation: Quantitative T2 values of ASL spins may then inform their local microenvironment.
Goal(s): In this study, we aim to conduct a technical development to demonstrate the feasibility of measuring ASL T2 at long post-labeling-delay (PLD), at a time when the spins have fully exited the vasculature.
Approach: A protocol comprised of Pseudo-Continuous Arterial Spin Labeling (PCASL) module followed by optimized background suppression pulses and 2D multiple-spin-echo (MSE) EPI readout was used to collect T2-weighted images at different post labeling delay (PLD).
Results: We estimated T2 of ASL difference signals at long PLDs and also find age related changes in T2 values.
Impact: Our result suggests that ASL spins may be used as a reporting probe to assessment the microvascular environment of the brain in health and diseases.
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