Keywords: Perfusion, Perfusion, DSC
Motivation: Transient hypoxia-induced BOLD-DSC perfusion imaging approach can noninvasively map cerebral blood flow (CBF) and cerebral blood volume (CBV). However, the reproducibility of this technique has not been previously assessed.
Goal(s): We aimed to determine the reproducibility of BOLD-DSC measurements within a single session and across multiple sessions.
Approach: The reproducibility of trial-wise BOLD-DSC measurements within each session was assessed for each animal during week 1, while the reproducibility of weekly BOLD-DSC measurements was evaluated across all animals from week 1 to week 4.
Results: We found that reproducibility and sensitivity of hypoxia-induced BOLD changes were consistently high in both single and multiple sessions.
Impact: The hypoxic challenge induces highly sensitive and reproducible BOLD responses across trials within a single session and consistently across multiple sessions, enabling the longitudinal and repetitive mapping of cerebral perfusion with easily implementable whole-brain BOLD-DSC MRI in mice.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords