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Abstract #2032

1H-MRSI of white matter in cognitively unimpaired elderly for the detection of early Alzheimer’s disease pathological changes

Anna M Chen1,2,3, Helena Zheng1,2, Rosemary Peralta1,2, Mia Gajdošík1,2, Dishari Azad4, Ajax George1,2, Henry Rusinek1,2, Allal Boutajangout5,6, Sinyeob Ahn7, Ricardo Osorio4, and Ivan I Kirov1,2,3,6
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 3Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, 4Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 5Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United States, 6Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 7Siemens Medical Solutions USA Inc., Malvern, PA, United States

Synopsis

Keywords: White Matter, White Matter, Aging, Alzheimer's Disease, Spectroscopy

Motivation: APOE4 has been linked to increased amyloid and tau deposition and microstructural WM changes in Alzheimer’s, but despite the major role of APOE in myelination, whether WM metabolism is altered in individuals at risk for Alzheimer’s remains unknown.

Goal(s): To examine if choline, a constituent of myelin and a marker of membrane turnover, is associated with APOE4, CSF p-tau181 (a marker of tau burden), and WM volume (a marker of neurodegeneration).

Approach: Cognitively unimpaired elderly with and without APOE4 underwent 1H-MRSI. Relationships between WM choline, APOE4, tau, and WM volume were assessed.

Results: No associations were found between WM choline and any marker.

Impact: WM metabolism is not associated with genotype, tau, or neurodegeneration in healthy elderly, but given that amyloid deposition is the earliest Alzheimer’s pathological hallmark, additional investigations with amyloid biomarkers are needed to better characterize WM metabolism in the preclinical stage.

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Abstract

Keywords