Keywords: Head & Neck/ENT, Head & Neck/ENT
Motivation: The underlying structural pathophysiology of visual white matter degeneration in primary open-angle glaucoma (POAG) remains incompletely understood.
Goal(s): To characterize macro- and micro-structural abnormalities in the optic tract and optic radiation of POAG by multiple morphology and diffusion metrics derived from diffusion spectrum imaging(DSI)
Approach: DSI was performed on 34 bilateral POAG patients and 25 healthy controls (HCs), and multiple morphology and diffusion metrics were calculated and compared.
Results: Significant differences emerged in morphology and diffusion metrics between POAG patients and HCs.
Impact: Our demonstration of multiple morphology and diffusion changes in POAG utilizing DS suggests the macro- and micro-structural white matter abnormalities, which could be used for assessing POAG degenetation
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