Abstract #2062

Association between cerebral blood flow and cerebral small vessel disease: a comparison between ASL and phase-contrast MRI

Linyun Xie¹, Jiaxin Zheng², Yao Zhang¹, Hui Hong¹, Shan Xu¹, Lei Cui¹, Shuyue Wang¹, Jixuan Li¹, Lingyun Liu¹, Miao Lin¹, Luo Xiao¹, Kaicheng Li¹, Qingze Zeng¹, Minming Zhang¹, Ruiting Zhang¹, Li Zhao², and Peiyu Huang¹

¹The 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Synopsis

Keywords: White Matter, Brain

Motivation: Chronic hypoperfusion is a central mechanism of cerebral small vessel disease (CSVD), but studies using different methods have shown different results.

Goal(s): To compare the associations between CSVD and CBF measured by phase-contrast MRI and ASL in the same cohort.

Approach: 69 subjects were totally recruited in the study. WMH, FW, and tFA were used to reflect the disease severity. The associations between CSVD and CBF measured by two methods were investigated.

Results: Compared to CBF_PC, CBF_ASL showed a negative association with FW and a positive association with tFA. The ratio of CBF_ASLto CBF_PC was also correlated with FW and tFA.

Impact: Future studies need to consider the differences between CBF measured by ASL and phase-contrast MRI and choose a more appropriate method according to the research purpose.

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