Keywords: Infectious Disease, COVID-19, brain changes, Omicron, young adults, mild symptom, SARS-CoV-2
Motivation: The existence of brain structural abnormalities in young adults with mild Omicron infections remains unclear.
Goal(s): This study aimed to investigate short-term brain structure changes in this specific patient group.
Approach: Young adult patients and age- and sex-matched controls were enrolled, and brain structures were assessed on T1-MPRAGE images. One-way ANOVA, Kruskal-Wallis tests, and logistic regression were employed to determine differences among groups.
Results: While whole brain volume didn't significantly differ among groups, subtle alterations in various regions within cerebral cortex, white matter, and cerebrospinal fluid were observed during the acute phase, with a tendency of recovery over time.
Impact: Short-term structural changes in brain were observed in this study. The findings suggest cerebral impairments at the early stage of infection with SARS-CoV-2 Omicron even in individuals with mild symptoms.
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