Keywords: Diffusion Analysis & Visualization, Diffusion/other diffusion imaging techniques, brain tumor
Motivation: Imaging microstructural parameters using limited spectrally edited diffusion (IMPULSED) based on time-dependent diffusion MRI (dMRI) could be utilized to quantify cell size, cellularity, and extracellular space, but its ability to distinguish common brain tumors remains unknown.
Goal(s): To determine the capacity of IMPULSED to distinguish between glioma, brain metastases, and meningioma.
Approach: Time-dependent dMRI was performed on patients with untreated glioma (n = 24), brain metastases (n = 67), and meningioma (n = 38). These patients’ IMPULSED-based parameters were evaluated and compared.
Results: Glioma, brain metastasis, and meningioma have distinctive IMPULSED-based parameters.
Impact: IMPULSED-based parameters could distinguish glioma, brain metastases, and meningioma. Time-dependent diffusion MRI is a potential approach for assessing the microstructures of brain tumors.
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