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Abstract #2169

Fast full-brain relaxometry in the clinic using MR-STAT

Martin B Schilder1, Stefano Mandija1, Sarah M Jacobs2, Jordi PD Kleinloog1, Hanna Liu1, Oscar van der Heide1, Beyza Köktaş1, Federico D'Agata3, Vera CW Keil4, Tom J Snijders5, Evert-Jan PA Vonken 5, Jan Willem Dankbaar5, Jeroen Hendrikse5, Cornelis AT van den Berg1, Anja G van der Kolk5,6, and Alessandro Sbrizzi1
1Computational Imaging Group for MR Therapy and Diagnostics, UMC Utrecht, Utrecht, Netherlands, 2Department of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, Netherlands, 3Department of Neurosciences, University of Turin, Turin, Italy, 4Department of Radiology, Amsterdam UMC, Amsterdam, Netherlands, 5Department of Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 6Department of Medical Imaging, Radboud UMC, Nijmegen, Netherlands

Synopsis

Keywords: Relaxometry, Quantitative Imaging, Relaxometry, MR-STAT, Clinical

Motivation: This is the first work assessing quantitative values (T1 and T2) from Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) as a fast relaxometry technique in clinical setting.

Goal(s): To assess MR-STAT as viable option for fast relaxometry in the clinic.

Approach: We applied MR-STAT to investigate the quantitative T1 and T2 values of brain tissue at 3T in a heterogeneous cohort of 50 subjects (10 healthy volunteers, mixed-pathology 40 patients).

Results: Quantitative values in normal appearing brain tissue were comparable to earlier literature. Furthermore, individual case examples (glioma, multiple sclerosis) confirmed the ability to discern pathological tissue in T1 and T2 values.

Impact: Voxel values in clinical MRI are subjective. Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) quickly quantifies MR tissue properties and gives voxels quantitative values. This work demonstrates MR-STAT as fast relaxometry technique in a clinical population and assesses quantitative values.

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Abstract

Keywords