Keywords: Relaxometry, Modelling, Microstructure, Nervous System
Motivation: T1 estimations using the MP2RAGE methodology are biased by Magnetization Transfer (MT) effects. A quantitative MT-based solution was previously proposed in which the inversion efficiency of the preparation pulse (Q) was fixed; we sought to alleviate this strong hypothesis.
Goal(s): To better understand the influence of free water T2 (T2,f) on Q in the scope of MP2RAGE-T1 brain mapping.
Approach: A better modeling of the MP2RAGE involving a discretized preparation pulse is employed, and tested for fixed and free T2,f values.
Results: The T1 bias is highly dependent on the T2,f values, calling for a better and accurate estimation of this parameter.
Impact: Quantitative MT-derived T1 estimation in the MP2RAGE methodology remains dependent on the estimated free water T2 values because of its impact on the inversion efficiency pulse.
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