Abstract #2175

**Myelin water fraction mapping of in-vivo and ex-vivo human brains at 3T and 7T**

Guojun Xu¹, Zhiyong Zhao¹, Qinfeng Zhu¹, Zuozhen Cao¹, Yiqi Shen¹, Yao Shen¹, Sihui Li¹, Keqing Zhu^2,3, Jing Zhang^2,3, and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China, ³Department of Pathology, The First Affiliated Hospital and School of Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Relaxometry, Multi-Contrast, Myelin Water Imaging

Motivation: Multi-echo gradient-echo (mGRE) MRI enabled non-invasive quantification of myelin water fraction (MWF) of the human brain.

Goal(s): The MWF may depend on field strength that changes the T₂^* decay and the results need to be verified by histological staining.

Approach: We performed mGRE-based MWF on in-vivo and ex-vivo human brain at high resolution and revealed the accuracy of the measurements using histological staining at both 3T and 7T.

Results: The MWF-derived from 7T was systematically higher than those from 3T and the in-vivo and ex-vivo measurements showed good agreement. The MWF at 3T and 7T both demonstrated good correlations with myelin basic protein.

Impact: These findings indicated the MWF mapping could reliably depict the myelin content in the human brain, although the measurement were field-strength dependent.

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