Abstract #2197

Quantitative Hemodynamic Measurements of the Posterior Circulation in Moyamoya Disease Patients using Arterial Spin Labeling Dynamic MRA

Hongwei Li¹, Xingfeng Shao², Gustavo Solcia³, Sihui Wang⁴, Yuriko Suzuki⁵, Danny J.J. Wang², He Wang^1,6, and Zhensen Chen^1,6

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ³São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil, ⁴Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁵University of Oxford, Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom, ⁶Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Blood Vessels, Velocity & Flow, ASL

Motivation: Hemodynamic information in the posterior circulation of Moyamoya disease (MMD) patient is crucial and may hint collateral flow.

Goal(s): To assess feasibility of hemodynamic quantification for the posterior circulation of MMD patients based on ASL dynamic MRA.

Approach: The model-free aBF quantification method based on ASL dynamic MRA, CFD simulation and 3D phase contrast (PC) were compared in the posterior circulation and the circle of Willis.

Results: As compared to CFD, aBF demonstrated better an agreement with PC results and had the potential for quantifying distal vessels. However, its accuracy may be influenced by the choice of AIF.

Impact: This study provides preliminary evidence regarding the feasibility of using ASL dynamic MRA to quantify the flow hemodynamics in Moyamoya disease patients.

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