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Abstract #2223

Uncertainty-Aware Anatomical Brain Parcellation using Diffusion MRI

Chenjun Li1, Ye Wu2, Le Zhang1, Qiannuo Li3, Shuyue Wang4, Shun Yao5, Kang Ik Kevin Cho6, Johanna Seitz-Holland6, Lipeng Ning6, Jon Haitz Legarreta6, Yogesh Rathi6, Carl-Fredrik Westin6, Lauren J. O'Donnell6, Ofer Pasternak6, and Fan Zhang1
1University of Electronic Science and Technology of China, Chengdu, China, 2Nanjing University of Science and Technology, Nanjing, China, 3East China University of Science and Technology, Shanghai, China, 4The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 5The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 6Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Analysis/Processing, Machine Learning/Artificial Intelligence, Diffusion MRI

Motivation: While anatomical brain parcellation has long been performed using anatomical MRI and atlas-based approaches, deep learning methods together with diffusion MRI techniques can improve parcellation performance and interpretation of prediction uncertainty.

Goal(s): Our goal is to design an uncertainty-aware deep learning network to utilize multiple diffusion MRI parameters for accurate brain parcellation while enabling voxel-level uncertainty estimation.

Approach: We include five evidential deep learning subnetworks and perform an evidence-based ensemble for parcellation prediction and uncertainty estimation.

Results: The results demonstrate our method’s superior parcellation performance over several state-of-the-art methods, its promising results in unseen patient scans, and potential applications in brain abnormality detection.

Impact: The proposed approach enables improved accuracy in brain parcellation from diffusion MRI, facilitating the understanding of the human brain in health and disease. It may also serve as an effective tool for brain abnormality detection, fostering inquiries into uncertainty-quantified diagnostics.

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Keywords