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Abstract #2230

Neural Network-based MR Elastography Wave Inversion Using Physics-based Simulations and Uncertainty Quantification

Héloïse Bustin1,2, Tom Meyer1, Jakob Jordan1, Rolf Reiter1,3, Lars Walczak1,2,4, Heiko Tzschätzsch1,5, Ingolf Sack1, and Anja Hennemuth1,2,4,6
1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany, 3Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany, 4Fraunhofer MEVIS, Berlin, Germany, 5Institute of Medical Informatics, Berlin, Germany, 6DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany

Synopsis

Keywords: AI/ML Image Reconstruction, Elastography

Motivation: In Magnetic Resonance Elastography (MRE), accurate reconstruction of stiffness maps is essential for medical diagnosis. Traditional inversion techniques are limited by noise, discretization and/or low wavenumbers.

Goal(s): We aim to overcome these limitations using a neural network-based wave inversion (ElastoNet) with integrated uncertainty quantification ensuring reliable predictions with high detail resolution.

Approach: We trained ElastoNet on simulated wave patches. For inference, we combined all 3 motion encoding directions as input and used evidential deep learning as an uncertainty quantification method.

Results: ElastoNet achieves a substantial improvement in detail resolution compared to current neural network approaches and shows promising results in the low-frequency domain.

Impact: Our MR elastography neural network-based wave inversion is a promising method for enhanced accuracy and reliability in tissue property characterization. It effectively addresses challenges in reconstruction of stiffness maps, expanding the potential of MR elastography for medical diagnosis.

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