Abstract #2255

The influence of fat-suppression on T2 values and texture features in articular cartilage

Pavol Szomolanyi^1,2, Vladimir Juras¹, Stefan Toegel³, Markus Schreiner³, Veronika Janacova¹, Didier Laurent⁴, Franziska Saxer⁴, Rahel Heule⁵, Oliver Bieri⁶, Esther Raithel⁷, Christoph Fuchssteiner⁸, Wolfgang Weninger⁸, Reinhard Windhager³, and Siegfried Trattnig^1,9,10,11

¹Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Imaging Methods, Institute of Measurement Science, Bratislava, Slovakia, ³Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria, ⁴Department of translational Medicine, Novartis Biomedical Research, Basel, Switzerland, ⁵Center for MR Research, University Children's Hospital, Zurich, Switzerland, ⁶Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, ⁷Siemens Healthcare AG, Forchheim, Germany, ⁸Center for Anatomy and Cell Biology, Division of Anatomy, Medical University of Vienna, Vienna, Austria, ⁹CD Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, ¹⁰Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, ¹¹Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria

Synopsis

Keywords: Cartilage, Cartilage

Motivation: If fat signal is not properly suppressed, it can lead to errors in the T2 calculations in human articular cartilage.

Goal(s): This work aimed to quantify the influence of fat suppression on T2 values as well as texture features extracted from T2 maps.

Approach: Ten donors were scanned in 3T MRI with DESS, T2-TESS and CPMG with and without fat suppression.

Results: The results of this study showed the importance of using fat suppression while acquiring T2 maps. The influence of fat suppression was substantially greater for CPMG-T2-mapping compared to TESS-T2-mapping.

Impact: If fat signal is not properly suppressed, it can lead to errors in the T2 calculations in human articular cartilage which can have a significant impact on longitudinal clinical trials.

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