Abstract #2258

T2* Cartilage Mapping in Early Axial Spondyloarthritis: Diagnostic Accuracy and Correlation with Clinical Characteristics and Sacroiliitis

Hongjie Huang^1,2, Yuyang Zhang¹, Feifei Zhuang¹, Xi Liu¹, Keyi Wu¹, Feng Wang¹, Xiance Zhao³, and Dairong Cao^1,2,4

¹Department of Radiology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China, ²Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China, ³Philips Healthcare, Shanghai, China, ⁴Department of Radiology, Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China

Synopsis

Keywords: Osteoarthritis, Bone

Motivation: Cartilage degradation has been recognized as an early and crucial feature in axSpA.

Goal(s): The objectives of the present study were (1) to determine the performance of T2^* cartilage mapping in diagnosing and assessing disease activity in early axSpA, (2) to investigate the interaction of cartilage damage with clinical characteristics and sacroiliitis.

Approach: Sacroiliac joints cartilage T2^* values were higher in patients with early axSpA compared to controls without axSpA.

Results: The combination of T2^* values and ‘positive MRI’ improve diagnostic efficiency of axSpA. Sacroiliac joints cartilage damage correlates with age, disease activity, acute sacroiliitis, and structural damage.

Impact: T2* relaxation time may be a promising imaging biomarker for diagnosing and differentiating disease activity in early axSpA. T2* mapping could be a recommended addition to routine MRI protocol of SIJs.

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