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Abstract #2261

Quantitative Ultrashort Echo Time Double Echo Steady State (qUTE-DESS) for T1, T2, and Diffusivity Mapping of Human Cartilage

Hyungseok Jang1, Soo Hyun Shin1, Dina Moazamian1, Yajun Ma1, Jiang Du1,2,3, Christine B. Chung1,4, and Eric Y. Chang1,4
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, 3Bioengineering, University of California, San Diego, San Diego, CA, United States, 4Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Cartilage, Cartilage, UTE, DESS, UTE-DESS, Diffusion, T1, T2

Motivation: A comprehensive validation of parameter mapping for T1, T2, and ADC based on qUTE-DESS has not been conducted yet.

Goal(s): To investigate the feasibility and accuracy of qUTE-DESS for estimating T1, T2, and ADC parameters in human patellar cartilage and to compare these results with conventional MR techniques.

Approach: The study used a qUTE-DESS sequence with variable flip angles and gradient moment adjustments. The cartilage sample was imaged using this approach and conventional imaging sequences, and the acquired data were processed using signal fitting.

Results: Significant correlations exist between the parameters estimated by qUTE-DESS and those from conventional sequences.

Impact: This study pioneers the comprehensive validation of T1, T2, and ADC parameter mapping using qUTE-DESS for knee joint imaging. Its findings offer a promising avenue to enhance the assessment of short T2 tissues and advance clinical applications in musculoskeletal diagnostics.

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Keywords