Abstract #2283

Quantitative Assessment of Meniscal Degeneration Using Three-dimensional Ultrashort Echo Time Adiabatic T1ρ (3D UTE-AdiabT1ρ) Imaging

Mei Wu^1,2, Yajun Ma², Xiaotong Liu¹, Xiaodong Zhang^2,3, Yi Wang^1,4, Saeed Jerban², Dana C. Covey⁵, Susan V Bukata⁵, Eric Y Chang^2,6, and Jiang Du^2,6

¹Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ²Department of Radiology, University of California San Diego, San Diego, CA, United States, ³Department of Radiology, the third affiliated hospital of Southern Medical University, Guangzhou, China, ⁴Tianhe District Maternal and Child Hospital of Guangzhou, Guangzhou, China, ⁵Department of Orthopaedic Surgery, University of California San Diego, San Diego, CA, United States, ⁶Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Osteoarthritis, Osteoarthritis

Motivation: The three-dimensional ultrashort echo time adiabatic T1ρ (3D UTE-AdiabT1ρ) sequence can provide magic angle-insensitive evaluation of proteoglycan depletion in both short- and long-T2 tissues in the knee joint.

Goal(s): Our goal was to assess its clinical performance.

Approach: We applied this sequence to healthy volunteers and patients with different degrees of osteoarthritis.

Results: The sequence could be used for quantitative evaluation of meniscus degeneration. The UTE-AdiabT1ρvalues in different subregions showed a significant positive relationship with WORMS, Stoller grades and KL groups. The 3D UTE-AdiabT1ρbiomarker can diagnose meniscal degeneration at an early stage.

Impact: The 3D UTE-AdiabT1ρ sequence allows quantitative imaging of the menisci. The UTE-AdiabT1ρ biomarker can diagnose meniscal degeneration at an early stage. Early detection of compositional changes in the menisci is of critical importance in avoiding or slowing down OA progression.

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