Abstract #2286

Reducing inter scanner variability using Voxel-based relaxometry and Z-score normalization: 6 years Longitudinal Study of Hip-OA patients

RAFEEK THAHAKOYA¹, MISUNG HAN¹, KOREN ROACH^1,2,3, RUPSA BHATTACHARJEE¹, FEI JIANG⁴, VALENTINA PEDOIA¹, RICHARD SAUZA¹, and SHARMILA MAJUMDAR¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Biomedical Engineering, University of Calgary, Canada, Calgary,, AB, Canada, ³Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁴Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Cartilage, Quantitative Imaging

Motivation: It is important to examine and correct inter-scanner variability of T1rho/T2 values to improve the accuracy of longitudinal studies

Goal(s): To evaluate the inter-scanner variability of T1rho/T2 values and measure longitudinal changes in hip cartilage T1rho/T2 values after calibration.

Approach: TCalibrate the hip cartilage T1rho/T2 values using Voxel-based relaxometry and Z-score normalization techniques

Results: The T1rho/T2 values showed that there was no statistically significant cartilage region (p<0.05) between the scanners. The longitudinal results showed an increase in number of subjects showing positive slope was increased in T1rho/T2 values after calibration (36.84 and 34.21%) compared without calibration (15.8% for both T1rho/T2).

Impact: The technique used for reducing the inter-scanner variability of T1rho/T2 values may benefit the longitudinal assessments of hip OA, specifically for evaluating disease progression over time on different scanners/before and after scanner upgrades

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