Abstract #2306

Assessment of a long label duration in multi-delay pseudo-continuous arterial spin labelling scheme

Makoto Obara¹, Osamu Togao², Ryoji Mikayama^3,4, Tatsuhiro Wada^3,4, Chiaki Tokunaga³, Lena Vaclavu⁵, Matthias J.P. van Osch⁵, Shota Ishida⁶, Kim van de Ven⁷, Yuki Ito¹, Hiroshi Hamano¹, Yu Ueda¹, Kwon Jihun ¹, Masami Yoneyama¹, and Marc Van Cauteren⁸

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Division of Radiological Technology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, ⁴Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁶Kyoto College of Medical Science, Kyoto, Japan, ⁷Philips Healthcare, Best, Netherlands, ⁸Philips Healthcare, Tokyo, Japan

Synopsis

Keywords: Stroke, Perfusion, ASL

Motivation: Clinical usefulness of multi-delay (MD) as well as long label duration (LD) pseudo-continuous arterial spin labelling (pCASL) have been suggested. However, MD-pCASL scheme including long LD has not been established.

Goal(s): Long LD combined MD-pCASL scheme was assessed in terms of quantification. The possibility of scan acceleration was also studied.

Approach: MD-pCASL with maximum LD 3 sec for 11 (3min 13sec) and 5 delays (1min 38sec) were assessed, and compared to a scheme with maximum LD 2 sec.

Results: Reasonable quantitative values were obtained by both LD 3 sec schemes, while providing higher SNR.

Impact: The potential of a MD-ASL scheme with long label duration has been demonstrated in terms of improved SNR, reasonable quantitative parameters, and acceleration of scan time. Advantages of the scheme are especially expected for neurovascular applications.

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