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Abstract #2312

The value of NODDI in detecting the changes of brain microstructure in rabbit models with early cerebral ischemia

Jiali Sun1, Yue Chen1, Min Lv1, Wei Wang1, Jianxiu Lian2, Sicong Huang2, and Yuefei Ma2
1First Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: Stroke, Brain, Cerebral ischemia, NODDI, Vic, ODI

Motivation: It is currently unclear whether neurite orientation dispersion and density imaging (NODDI) can reflect the microstructure in early cerebral hypoperfusion.

Goal(s): Therefore, this study aims to detect the cerebral microstructure using NODDI in rabbits’ cerebral ischemia model.

Approach: The orientation dispersion index (ODI) and intracellular volume fraction (Vic) were calculated for comparing among groups, including pre-operative and post-operative of rabbit models, and control group.

Results: The results showed that Vic of bilateral cerebral hemispheres in post-operative state was higher than that of pre-operative and control groups (all P < 0.05). NODDI could be used to reflect the mild injury in early cerebral ischemia.

Impact: Early recognition of injury in brain tissue microstructure in patients with cerebral ischemia is helpful to guide clinical treatment, and NODDI will be able to identify early brain injury.

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Keywords

cerebralnoddi