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Abstract #2315

Neurovascular characterization of early brain injury in subarachnoid hemorrhage with Multi-modality MRI (1H and 23Na)

Yuanyuan Jiang1, Takahiko Imai2, James Han Lai2, Xiaoqing Alice Zhou1, David Hike1, Sohail Mohammed1, Cenk Ayata2,3, David Chung2,3, and Xin Yu1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 3Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Synopsis

Keywords: Stroke, Traumatic brain injury

Motivation: This work is to identify d 23Na (sodium) as a biomarker for early brain injuries (EBI) after subarachnoid hemorrhage (SAH).

Goal(s): This research utilizes a novel head-implanted coil to measure 1H and 23Na whole-brain MRI for characterization of EBI.

Approach: We achieved acquisition of 1H for anatomical templates and 23Na MRI images at an impressive spatial resolution of 300x300x500 µm.

Results: We surprisingly observed that the 23Na signal precedes the appearance of conventional 1H diffusion-weighted signal after SAH-related brain injury. Also, a concentration gradient distribution of 23Na mapping within the EBI regions demonstrated a finer granularity not typically depicted by conventional 1H MRI.

Impact: This work revealed the distinct 23Na dynamics for EBI detection and highlighted the critical usage of a multi-modal platform to specify the EBI after SAH.

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Abstract

Keywords