Abstract #2323

Increased T2 value suggest the NA-CST degeneration following stroke proved by multiple overlapping-echo detachment qMRI

Jianfeng Bao¹, Xiao Wang¹, Ming Ye², Qinqin Yang², Congbo Cai², Shuhui Cai², Andrey Tulupov³, Yanbo Dong⁴, Liangjie Lin⁵, Yong Zhang¹, Zhong Chen², and Jingliang Cheng¹

¹Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China, ²Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, School of Electronic Science and Engineering, National Model Microelectronics College, Xiamen University, Xiamen, China, ³The Laboratory «MRT TECHNOLOGIES», The Institute International Tomography Center of the Russian Academy of Sciences, Novosibirsk, Russian Federation, ⁴Pingdingshan College, Pingdingshan, China, ⁵Philips Healthcare, Beijing, China

Synopsis

Keywords: Stroke, Stroke

Motivation: Stroke patients commonly face challenges during clinical magnetic resonance imaging (MRI) examinations due to loss of consciousness and involuntary movements. This study aims to address these challenges using a self-developed ultra-fast, multiple overlapping-echo detachment (MOLED) quantitative magnetic resonance technology.

Goal(s): Through this technology, we seek to quantitatively detect potential damage to the motor-related normal-appearing corticospinal tract (NA-CST) following stroke.

Approach: Total 79 patients underwent routine scan and MOLED. A deep learning network was utilized for quantitative image reconstruction.

Results: MOLED T2 imaging showed high accuracy and repeatability, was unaffected by head motion, correlated with motor dysfunction severity, and predicted motor impairment post-stroke.

Impact: The MOLED technique quickly and accurately quantifies imaging in stroke patients with involuntary movements and helps monitor post-stroke motor impairment progression.

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